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Article

CD1-restricted adaptive immune responses to Mycobacteria in human group 1 CD1 transgenic mice.

The Journal of experimental medicine - 26 Oct 2009

Felio Kyrie, Nguyen Hanh, Dascher Christopher C, Choi Hak-Jong, Li Sha, Zimmer Michael I, Colmone Angela, Moody D Branch, Brenner Michael B, Wang Chyung-Ru

Abstract excerpt

Group 1 CD1 (CD1a, CD1b, and CD1c)-restricted T cells recognize mycobacterial lipid antigens and are found at higher frequencies in Mycobacterium tuberculosis (Mtb)-infected individuals. However, their role and dynamics during infection remain unknown because of the lack of a suitable small animal model. We have generated human group 1 CD1 transgenic (hCD1Tg) mice that express all three human group 1 CD1 isoforms...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19808251
DOI: 10.1084/jem.20090898
PMCID: PMC2768849

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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