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Article

A Novel Murine Model of Hemophagocytic Lymphohistiocytosis-Like Inflammation in ZNFX1 Deficiency.

European journal of immunology - 1 Feb 2026

Tintor Diana, Milanesi Samantha, Marchetti Tommaso, Lorenzini Tiziana, Walser Severin, Chen Junyi, Köppen Julius, Weber Achim, Sabet Ola, Pachlopnik Schmid Jana

Abstract excerpt

Hemophagocytic lymphohistiocytosis (HLH) is a severe inflammatory syndrome characterized by persistent activation of lymphocytes and macrophages. Recently, deleterious autosomal recessive mutations in ZNFX1 were reported to predispose pediatric patients to HLH-like disease upon viral trigger. The objective of this study was to assess the suitability of Znfx1-mutant (Znfx1mut) mice infected with lymphocytic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41636200
DOI: 10.1002/eji.70141
PMCID: PMC12869469

Genes

ZNFX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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