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Article

An Unusual MHC Molecule Generates Protective CD8+ T Cell Responses to Chronic Infection.

Frontiers in immunology - 1 Jan 2020

Tsitsiklis Alexandra, Bangs Derek J, Lutes Lydia K, Chan Shiao W, Geiger Kristina M, Modzelewski Andrew J, Labarta-Bajo Lara, Wang Yang, Zuniga Elina I, Dai Shaodong, Robey Ellen A

Abstract excerpt

The CD8+ T cell response to the intracellular parasite Toxoplasma gondii varies dramatically between mouse strains, resulting in stark differences in control of the parasite. Protection in BALB/c mice can be attributed to an unusually strong and protective MHC-1 Ld-restricted CD8+ T cell response directed against a peptide derived from the parasite antigen GRA6. The MHC-1 Ld molecule has limited peptide binding...

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Source

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Identifiers

PMID: 32733483
DOI: 10.3389/fimmu.2020.01464
PMCID: PMC7360836

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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