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Article

Secreted gelsolin inhibits DNGR-1-dependent cross-presentation and cancer immunity.

Cell - 22 Jul 2021

Giampazolias Evangelos, Schulz Oliver, Lim Kok Haw Jonathan, Rogers Neil C, Chakravarty Probir, Srinivasan Naren, Gordon Oliver, Cardoso Ana, Buck Michael D, Poirier Enzo Z, Canton Johnathan, Zelenay Santiago, Sammicheli Stefano, Moncaut Natalia, Varsani-Brown Sunita, Rosewell Ian, Reis e Sousa Caetano

Abstract excerpt

Cross-presentation of antigens from dead tumor cells by type 1 conventional dendritic cells (cDC1s) is thought to underlie priming of anti-cancer CD8+ T cells. cDC1 express high levels of DNGR-1 (a.k.a. CLEC9A), a receptor that binds to F-actin exposed by dead cell debris and promotes cross-presentation of associated antigens. Here, we show that secreted gelsolin (sGSN), an extracellular protein, decreases DNGR-1...

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Source

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Identifiers

PMID: 34081922
DOI: 10.1016/j.cell.2021.05.021
PMCID: PMC8320529

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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