Article
Cutting edge: the SLAM family receptor Ly108 controls T cell and neutrophil functions.
Journal of immunology (Baltimore, Md. : 1950) - 15 May 2005
Howie Duncan, Laroux F Stephen, Morra Massimo, Satoskar Abhay R, Rosas Lucia E, Faubion William A, Julien Aimee, Rietdijk Svend, Coyle Anthony J, Fraser Christopher, Terhorst Cox
Abstract excerpt
Ly108, a glycoprotein of the signaling lymphocytic activation molecule family of cell surface receptors expressed by T, B, NK, and APCs has been shown to have a role in NK cell cytotoxicity and T cell cytokine responses. In this study, we describe that CD4(+) T cells from mice with a targeted disruption of exons 2 and 3 of Ly108 (Ly108(DeltaE2+3)) produce significantly less IL-4 than wild-type CD4(+) cells, as...
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