Article
T-cell-directed TAL-1 expression induces T-cell malignancies in transgenic mice.
Cancer research - 15 Nov 1996
Condorelli G L, Facchiano F, Valtieri M, Proietti E, Vitelli L, Lulli V, Huebner K, Peschle C, Croce C M
Abstract excerpt
The TAL-1 gene specifies for a basic domain-helix-loop-helix protein, which is involved in the control of normal hematopoiesis. In human pathology, the TAL-1 gene product is expressed in a high percentage of T-cell acute lymphoblastic leukemias in the pediatric age range; however, it has not been...
Topics
- Adenovirus E2 Proteins
- Animals
- Basic Helix-Loop-Helix Transcription Factors
- CD3 Complex
- DNA-Binding Proteins
- Gene Deletion
- Genes, p53
- Humans
- Leukemia-Lymphoma, Adult T-Cell
- Mice
- Mice, Inbred C57BL
- Mice, Transgenic
- Oncogene Proteins, Fusion
- Oncogenes
- Phenotype
- Proto-Oncogene Proteins
- RNA, Messenger
- Spleen