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Article

Tom1l2 hypomorphic mice exhibit increased incidence of infections and tumors and abnormal immunologic response.

Mammalian genome : official journal of the International Mammalian Genome Society - 1 Apr 2008

Girirajan Santhosh, Hauck Paula M, Williams Stephen, Vlangos Christopher N, Szomju Barbara B, Solaymani-Kohal Sara, Mosier Philip D, White Kimber L, McCoy Kathleen, Elsea Sarah H

Abstract excerpt

Studies have shown that the TOM1 family of proteins, including TOM1 and TOM1L1, are actively involved in endosomal trafficking and function in the immune response. However, much less is known about the function of TOM1L2. To understand the biological importance of TOM1L2 and the potential significance of its cellular role, we created and evaluated Tom1l2 gene-trapped mice with reduced Tom1l2 expression. Mice...

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Source

Identifiers

PMID: 18343975
DOI: 10.1007/s00335-008-9100-6

Genes

TOM1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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