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Article

Regulation of Brain-Derived Neurotrophic Factor Exocytosis and Gamma-Aminobutyric Acidergic Interneuron Synapse by the Schizophrenia Susceptibility Gene Dysbindin-1.

Biological psychiatry - 15 Aug 2016

Yuan Qiang, Yang Feng, Xiao Yixin, Tan Shawn, Husain Nilofer, Ren Ming, Hu Zhonghua, Martinowich Keri, Ng Julia S, Kim Paul J, Han Weiping, Nagata Koh-Ichi, Weinberger Daniel R, Je H Shawn

Abstract excerpt

BACKGROUND: Genetic variations in dystrobrevin binding protein 1 (DTNBP1 or dysbindin-1) have been implicated as risk factors in the pathogenesis of schizophrenia. The encoded protein dysbindin-1 functions in the regulation of synaptic activity and synapse development. Intriguingly, a loss of function mutation in Dtnbp1 in mice disrupted both glutamatergic and gamma-aminobutyric acidergic transmission in the...

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Source

Identifiers

PMID: 26386481
DOI: 10.1016/j.biopsych.2015.08.019

Genes

BDNF
DTNBP1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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