Article
Dysbindin-1 mutant mice implicate reduced fast-phasic inhibition as a final common disease mechanism in schizophrenia.
Proceedings of the National Academy of Sciences of the United States of America - 25 Oct 2011
Carlson Gregory C, Talbot Konrad, Halene Tobias B, Gandal Michael J, Kazi Hala A, Schlosser Laura, Phung Quan H, Gur Raquel E, Arnold Steven E, Siegel Steven J
Abstract excerpt
DTNBP1 (dystrobrevin binding protein 1) is a leading candidate susceptibility gene in schizophrenia and is associated with working memory capacity in normal subjects. In schizophrenia, the encoded protein dystrobrevin-binding protein 1 (dysbindin-1) is often reduced in excitatory cortical limbic synapses. We found that reduced dysbindin-1 in mice yielded deficits in auditory-evoked response adaptation, prepulse...
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