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Article

Potential molecular mechanisms for decreased synaptic glutamate release in dysbindin-1 mutant mice.

Schizophrenia research - 1 May 2013

Saggu Shalini, Cannon Tyrone D, Jentsch J David, Lavin Antonieta

Abstract excerpt

Behavioral genetic studies of humans have associated variation in the DTNBP1 gene with schizophrenia and its cognitive deficit phenotypes. The protein encoded by DTNBP1, dysbindin-1, is expressed in forebrain neurons where it interacts with proteins mediating vesicular trafficking and exocytosis. It has been shown that loss of dysbindin-1 results in a decrease in glutamate release in the prefrontal cortex;...

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Source

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Identifiers

PMID: 23473812
DOI: 10.1016/j.schres.2013.01.037
PMCID: PMC3628687

Genes

DTNBP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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