Article
Dysbindin (DTNBP1) and the biogenesis of lysosome-related organelles complex 1 (BLOC-1): main and epistatic gene effects are potential contributors to schizophrenia susceptibility.
Biological psychiatry - 1 Jan 2008
Morris Derek W, Murphy Kevin, Kenny Niamh, Purcell Shaun M, McGhee Kevin A, Schwaiger Siobhan, Nangle Jeanne-Marie, Donohoe Gary, Clarke Sarah, Scully Paul, Quinn John, Meagher David, Baldwin Patrizia, Crumlish Niall, O'Callaghan Eadbhard, Waddington John L, Gill Michael, Corvin Aiden P
Abstract excerpt
BACKGROUND: The DTNBP1 gene, encoding dysbindin, has been strongly implicated in schizophrenia (SZ) susceptibility by a series of independent genetic association and gene expression studies. Among its known functions, dysbindin is part of a protein complex, termed the biogenesis of lysosome-relat...
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