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Article

Evidence that the BLOC-1 protein dysbindin modulates dopamine D2 receptor internalization and signaling but not D1 internalization.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 7 Nov 2007

Iizuka Yukihiko, Sei Yoshitatsu, Weinberger Daniel R, Straub Richard E

Abstract excerpt

The schizophrenia susceptibility gene dystrobrevin-binding protein 1 (DTNBP1) encodes dysbindin, which along with its binding partner Muted is an essential component of the biogenesis of lysosome-related organelles complex 1 (BLOC-1). Dysbindin expression is reduced in schizophrenic brain tissue, but the molecular mechanisms by which this contributes to pathogenesis and symptomatology are unknown. We studied the...

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Source

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Identifiers

PMID: 17989303
DOI: 10.1523/JNEUROSCI.1689-07.2007
PMCID: PMC6673263

Genes

DRD2
DTNBP1
DRD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Evidence that the BLOC-1 protein dysbindin modulates dopamine D2 receptor internalization and signaling but not D1 internalization.PMID 17989303Read ↗

Cell biology of the BLOC-1 complex subunit dysbindin, a schizophrenia susceptibility gene.Semantic proximity Read ↗

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Quantitative proteomic and genetic analyses of the schizophrenia susceptibility factor dysbindin identify novel roles of the biogenesis of lysosome-related organelles complex 1.Semantic proximity Read ↗

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Dysbindin (DTNBP1) and the biogenesis of lysosome-related organelles complex 1 (BLOC-1): main and epistatic gene effects are potential contributors to schizophrenia susceptibility.Semantic proximity Read ↗

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