Article
Cell biology of the BLOC-1 complex subunit dysbindin, a schizophrenia susceptibility gene.
Molecular neurobiology - 1 Aug 2011
Mullin Ariana P, Gokhale Avanti, Larimore Jennifer, Faundez Victor
Abstract excerpt
There is growing interest in the biology of dysbindin and its genetic locus (DTNBP1) due to genetic variants associated with an increased risk of schizophrenia. Reduced levels of dysbindin mRNA and protein in the hippocampal formation of schizophrenia patients further support involvement of this locus in disease risk. Here, we discuss phylogenetically conserved dysbindin molecular interactions that define its...
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