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MeCP2 Regulates the Synaptic Expression of a Dysbindin-BLOC-1 Network Component in Mouse Brain and Human Induced Pluripotent Stem Cell-Derived Neurons

4 Jun 2013

Abstract excerpt

Clinical, epidemiological, and genetic evidence suggest overlapping pathogenic mechanisms between autism spectrum disorder (ASD) and schizophrenia. We tested this hypothesis by asking if mutations in the ASD gene MECP2 which cause Rett syndrome affect the expression of genes encoding the schizophrenia risk factor dysbindin, a subunit of the biogenesis of lysosome-related organelles complex-1 (BLOC-1), and...

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PMID: 23750231
DOI: 10.1371/journal.pone.0065069

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Related research

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Research trail→

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MeCP2 Regulates the Synaptic Expression of a Dysbindin-BLOC-1 Network Component in Mouse Brain and Human Induced Pluripotent Stem Cell-Derived NeuronsPMID 23750231Read ↗

Cell biology of the BLOC-1 complex subunit dysbindin, a schizophrenia susceptibility gene.Semantic proximity Read ↗

Mutations in the BLOC-1 subunits dysbindin and muted generate divergent and dosage-dependent phenotypes.Semantic proximity Read ↗

The Proteome of BLOC-1 Genetic Defects Identifies the Arp2/3 Actin Polymerization Complex to Function Downstream of the Schizophrenia Susceptibility Factor Dysbindin at the SynapseSemantic proximity Read ↗

The dysbindin-containing complex (BLOC-1) in brain: developmental regulation, interaction with SNARE proteins and role in neurite outgrowth.Semantic proximity Read ↗

Quantitative proteomic and genetic analyses of the schizophrenia susceptibility factor dysbindin identify novel roles of the biogenesis of lysosome-related organelles complex 1.Semantic proximity Read ↗

Dysbindin (DTNBP1) and the biogenesis of lysosome-related organelles complex 1 (BLOC-1): main and epistatic gene effects are potential contributors to schizophrenia susceptibility.Semantic proximity Read ↗

Prkn knockout mice show autistic-like behaviors and aberrant synapse formationSemantic proximity Read ↗

Evidence that the BLOC-1 protein dysbindin modulates dopamine D2 receptor internalization and signaling but not D1 internalization.Semantic proximity Read ↗

Regulation of Brain-Derived Neurotrophic Factor Exocytosis and Gamma-Aminobutyric Acidergic Interneuron Synapse by the Schizophrenia Susceptibility Gene Dysbindin-1.Semantic proximity Read ↗

Deciphering MECP2-associated disorders: disrupted circuits and the hope for repair.Semantic proximity Read ↗

Recognition deficits in mice carrying mutations of genes encoding BLOC-1 subunits pallidin or dysbindin.Semantic proximity Read ↗

Region-specific alterations of perineuronal net expression in postmortem autism brain tissueSemantic proximity Read ↗

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