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Innate Viral Sensor MDA5 and Coxsackievirus Interplay in Type 1 Diabetes Development

3 Jul 2020

Abstract excerpt

Type 1 diabetes (T1D) is a polygenic autoimmune disease characterized by immune-mediated destruction of insulin-producing β-cells. The concordance rate for T1D in monozygotic twins is ≈30–50%, indicating that environmental factors also play a role in T1D development. Previous studies have demonstrated that enterovirus infections such as coxsackievirus type B (CVB) are associated with triggering T1D. Prior to...

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Diabetes and associated disorders
interferon and immune responses
Viral Infections and Immunology Research

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 32635205
DOI: 10.3390/microorganisms8070993

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