Article
Molecular basis of the attenuated phenotype of human APOBEC3B DNA mutator enzyme.
Nucleic acids research - 30 Oct 2015
Caval Vincent, Bouzidi Mohamed S, Suspène Rodolphe, Laude Hélène, Dumargne Marie-Charlotte, Bashamboo Anu, Krey Thomas, Vartanian Jean-Pierre, Wain-Hobson Simon
Abstract excerpt
The human APOBEC3A and APOBEC3B genes (A3A and A3B) encode DNA mutator enzymes that deaminate cytidine and 5-methylcytidine residues in single-stranded DNA (ssDNA). They are important sources of mutations in many cancer genomes which show a preponderance of CG->TA transitions. Although both enzymes can hypermutate chromosomal DNA in an experimental setting, only A3A can induce double strand DNA breaks, even...
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