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Functions and Malfunctions of Mammalian DNA-Cytosine Deaminases

1 Sept 2016

Abstract excerpt

The AID/APOBEC family enzymes convert cytosines in single-stranded DNA to uracils, causing base substitutions and strand breaks. They are induced by cytokines produced during the body's inflammatory response to infections, and they help combat infections through diverse mechanisms. AID is essential for the maturation of antibodies and causes mutations and deletions in antibody genes through somatic hypermutation...

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PMID: 27585283
DOI: 10.1021/acs.chemrev.6b00296

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