Article
Powerful mutators lurking in the genome.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 12 Mar 2009
Petit Vincent, Vartanian Jean-Pierre, Wain-Hobson Simon
Abstract excerpt
The human genome encodes numerous enzymes capable of deaminating polynucleotides. While they are capable of exquisite specificity, occasionally they result in hypermutation where up to 90 per cent of cytidine or adenosine residues may be edited. As such, they constitute a formidable anti-viral barrier, for no virus can survive such a high mutation rate. As the APOBEC3 group of cytidine deaminases edit...
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