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Article

APOBEC3B: pathological consequences of an innate immune DNA mutator.

Biomedical journal - 1 Jan 2000

Burns Michael B, Leonard Brandon, Harris Reuben S

Abstract excerpt

Cancer is a disease that results from alterations in the cellular genome. Several recent studies have identified mutational signatures that implicate a variety of mutagenic processes in cancer, a major one of which is explained by the enzymatic activity of the DNA cytosine deaminase, APOBEC3B. As a deaminase, APOBEC3B converts cytosines to uracils in single-stranded DNA. Failure to properly repair these uracil...

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Identifiers

PMID: 25566802
DOI: 10.4103/2319-4170.148904

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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