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Article

Orthologous mammalian APOBEC3A cytidine deaminases hypermutate nuclear DNA.

Molecular biology and evolution - 1 Feb 2014

Caval Vincent, Suspène Rodolphe, Vartanian Jean-Pierre, Wain-Hobson Simon

Abstract excerpt

The human APOBEC3 gene cluster locus encodes polynucleotide cytidine deaminases. Although many act as viral restriction factors through mutation of single-stranded DNA, recent reports have shown that human APOBEC3A was capable of efficiently hypermutating nuclear DNA and inducing DNA breaks in genomic DNA. In addition, the enzyme was unique in efficiently deaminating 5-methylcytidine in single-stranded DNA. To...

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PMID: 24162735
DOI: 10.1093/molbev/mst195

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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