Article
A prevalent cancer susceptibility APOBEC3A hybrid allele bearing APOBEC3B 3'UTR enhances chromosomal DNA damage.
Nature communications - 9 Oct 2014
Caval Vincent, Suspène Rodolphe, Shapira Milana, Vartanian Jean-Pierre, Wain-Hobson Simon
Abstract excerpt
Human APOBEC3A (A3A) cytidine deaminase is a host enzyme that can introduce mutations into chromosomal DNA. As APOBEC3B (A3B) encodes a C-terminal catalytic domain ~91% identical to A3A, we examined its genotoxic potential as well as that of a highly prevalent chimaeric A3A-A3B deletion allele (ΔA3B), which is linked to a higher odds ratio of developing breast, ovarian and liver cancer. Interestingly, breast...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.