Article
Revealing very small FLT3 ITD mutated clones by ultra-deep sequencing analysis has important clinical implications in AML patients.
Oncotarget - 13 Oct 2015
Zuffa Elisa, Franchini Eugenia, Papayannidis Cristina, Baldazzi Carmen, Simonetti Giorgia, Testoni Nicoletta, Abbenante Maria Chiara, Paolini Stefania, Sartor Chiara, Parisi Sarah, Marconi Giovanni, Cattina Federica, Bochicchio Maria Teresa, Venturi Claudia, Ottaviani Emanuela, Cavo Michele, Martinelli Giovanni
Abstract excerpt
FLT3 internal tandem duplication (ITD), one of the most frequent mutations in Acute Myeloid Leukemia (AML), is reported to be an unstable marker, as it can evolve from FLT3 ITD- to ITD+ during the disease course. A single-gene sensitive mutational screening approach may be helpful for better clarifying the exact timing of mutation occurrence, especially when FLT3 ITD appears to occur late, at disease progression....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.