Article
Identification of emerging FLT3 ITD-positive clones during clinical remission and kinetics of disease relapse in acute myeloid leukaemia with mutated nucleophosmin.
British journal of haematology - 1 May 2013
Ottone Tiziana, Zaza Serena, Divona Mariadomenica, Hasan Syed Khizer, Lavorgna Serena, Laterza Serena, Cicconi Laura, Panetta Paola, Di Giandomenico Jonny, Cittadini Michela, Ciardi Claudia, Montefusco Enrico, Franchi Annibale, Annino Luciana, Venditti Adriano, Amadori Sergio, Lo-Coco Francesco
Abstract excerpt
FLT3 internal tandem duplication (ITD) mutations are frequently detected at diagnosis in cytogenetically normal acute myeloid leukaemia (CN-AML) and predict unfavourable outcome. FLT3 ITD is an unstable aberration and may be lost or acquired at relapse. Recent whole genome sequencing studies have suggested that FLT3 ITD(+)ve AML relapse may evolve from small subclones undetectable at diagnosis by routine...
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