Article
Profiling of somatic mutations in acute myeloid leukemia with FLT3-ITD at diagnosis and relapse.
Blood - 26 Nov 2015
Garg Manoj, Nagata Yasunobu, Kanojia Deepika, Mayakonda Anand, Yoshida Kenichi, Haridas Keloth Sreya, Zang Zhi Jiang, Okuno Yusuke, Shiraishi Yuichi, Chiba Kenichi, Tanaka Hiroko, Miyano Satoru, Ding Ling-Wen, Alpermann Tamara, Sun Qiao-Yang, Lin De-Chen, Chien Wenwen, Madan Vikas, Liu Li-Zhen, Tan Kar-Tong, Sampath Abhishek, Venkatesan Subhashree, Inokuchi Koiti, Wakita Satoshi, Yamaguchi Hiroki, Chng Wee Joo, Kham Shirley-Kow Yin, Yeoh Allen Eng-Juh, Sanada Masashi, Schiller Joanna, Kreuzer Karl-Anton, Kornblau Steven M, Kantarjian Hagop M, Haferlach Torsten, Lill Michael, Kuo Ming-Chung, Shih Lee-Yung, Blau Igor-Wolfgang, Blau Olga, Yang Henry, Ogawa Seishi, Koeffler H Phillip
Abstract excerpt
Acute myeloid leukemia (AML) with an FLT3 internal tandem duplication (FLT3-ITD) mutation is an aggressive hematologic malignancy with a grave prognosis. To identify the mutational spectrum associated with relapse, whole-exome sequencing was performed on 13 matched diagnosis, relapse, and remission trios followed by targeted sequencing of 299 genes in 67 FLT3-ITD patients. The FLT3-ITD genome has an average of 13...
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