Article
Tracking Response and Resistance in Acute Myeloid Leukemia through Single-Cell DNA Sequencing Helps Uncover New Therapeutic Targets.
International journal of molecular sciences - 17 Sept 2024
Bruno Samantha, Borsi Enrica, Patuelli Agnese, Bandini Lorenza, Mancini Manuela, Forte Dorian, Nanni Jacopo, Barone Martina, Grassi Alessandra, Cristiano Gianluca, Venturi Claudia, Robustelli Valentina, Atzeni Giulia, Mosca Cristina, De Santis Sara, Monaldi Cecilia, Poletti Andrea, Terragna Carolina, Curti Antonio, Cavo Michele, Soverini Simona, Ottaviani Emanuela
Abstract excerpt
Acute myeloid leukemia (AML) is an aggressive hematologic neoplasia with a complex polyclonal architecture. Among driver lesions, those involving the FLT3 gene represent the most frequent mutations identified at diagnosis. The development of tyrosine kinase inhibitors (TKIs) has improved the clinical outcomes of FLT3-mutated patients (Pt). However, overcoming resistance to these drugs remains a challenge. To...
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