Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Clonal Dynamics and Relapse Risk Revealed by High-Sensitivity FLT3-Internal Tandem Duplication Detection in Acute Myeloid Leukemia.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Sept 2024

Oduro Kwadwo Asare, Spivey Theresa, Moore Erika M, Meyerson Howard, Yoest Jennifer, Tomlinson Benjamin, Beck Rose, Alouani David, Sadri Navid

Abstract excerpt

The ability to detect low-level disease is key to our understanding of clonal heterogeneity in acute myeloid leukemia (AML) and residual disease that elude conventional assays and seed relapse. We developed a high-sensitivity next-generation sequencing (HS-NGS) clinical assay, able to reliably detect low levels (1 × 10-5) of FLT3-ITD, a frequent, therapeutically targetable and prognostically relevant mutation in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Clonal Evolution

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to fms-Like Tyrosine Kinase 3

Share to Gene Duplication

Share to High-Throughput Nucleotide Sequencing

Share to Leukemia, Myeloid, Acute

Share to Recurrence

Share to Tandem Repeat Sequences

Source

Identifiers

PMID: 38852814
DOI: 10.1016/j.modpat.2024.100534

Genes

FLT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Clonal Dynamics and Relapse Risk Revealed by High-Sensitivity FLT3-Internal Tandem Duplication Detection in Acute Myeloid Leukemia.PMID 38852814Read ↗

Next-generation sequencing of FLT3 internal tandem duplications for minimal residual disease monitoring in acute myeloid leukemia.Semantic proximity Read ↗

Clinical potential of introducing next-generation sequencing in patients at relapse of acute myeloid leukemia.Semantic proximity Read ↗

Profiling of somatic mutations in acute myeloid leukemia with FLT3-ITD at diagnosis and relapse.Semantic proximity Read ↗

Clonal Dynamics of FLT3-ITD from Diagnosis to Relapse: Ultra-Sensitive Patient-Specific Monitoring by ddPCR.Semantic proximity Read ↗

Clonal Evolution of Acute Myeloid Leukemia Revealed by High-Throughput Single-Cell GenomicsSemantic proximity Read ↗

Single-cell mutational profiling enhances the clinical evaluation of AML MRD.Semantic proximity Read ↗

Day + 30 detection of minimal residual FLT3-ITD by high-sensitivity PCR-NGS predicts relapse risk and guides post-transplant maintenance in AML.Semantic proximity Read ↗

Revealing very small FLT3 ITD mutated clones by ultra-deep sequencing analysis has important clinical implications in AML patients.Semantic proximity Read ↗

Comprehensive insights into AML relapse: genetic mutations, clonal evolution, and clinical outcomesSemantic proximity Read ↗

<em>FLT3</em>-ITD Measurable Residual Disease in Acute Myeloid Leukemia: Implications for <em>FLT3</em> Inhibitor-Based TherapiesSemantic proximity Read ↗

Next-generation sequencing-based posttransplant monitoring of acute myeloid leukemia identifies patients at high risk of relapse.Semantic proximity Read ↗

Deep Sequencing of FLT3-ITD Enables Response Evaluation and Post-Treatment Monitoring in Childhood AML: An Exploratory Study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.