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Article

Next-generation sequencing of FLT3 internal tandem duplications for minimal residual disease monitoring in acute myeloid leukemia.

Oncotarget - 8 Sept 2015

Bibault Jean-Emmanuel, Figeac Martin, Hélevaut Nathalie, Rodriguez Céline, Quief Sabine, Sebda Shéhérazade, Renneville Aline, Nibourel Olivier, Rousselot Philippe, Gruson Bérengère, Dombret Hervé, Castaigne Sylvie, Preudhomme Claude

Abstract excerpt

Minimal Residual Disease (MRD) detection can be used for early intervention in relapse, risk stratification, and treatment guidance. FLT3 ITD is the most common mutation found in AML patients with normal karyotype. We evaluated the feasibility of NGS with high coverage (up to 2.4.10(6) PE fragments) for MRD monitoring on FLT3 ITD. We sequenced 37 adult patients at diagnosis and various times of their disease (64...

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Source

Open in PubMed Open full text

Identifiers

PMID: 26078355
DOI: 10.18632/oncotarget.4333
PMCID: PMC4673201

Genes

FLT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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