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Deep Sequencing of FLT3-ITD Enables Response Evaluation and Post-Treatment Monitoring in Childhood AML: An Exploratory Study.

Pediatric blood & cancer - 1 Aug 2026

Alm Sofie Johansson, Tornberg Bea, Malmberg Erik Delsing, Hasle Henrik, Juul-Dam Kristian Løvvik, Palmqvist Lars, Saeed Borhan R, Barkhordar Giti Shah, Soboli Anastasia, Staffas Anna, Abrahamsson Jonas, Fogelstrand Linda

Abstract excerpt

BACKGROUND: An internal tandem duplication in the gene encoding Fms-like tyrosine kinase 3 (FLT3-ITD) is associated with high relapse risk and poor prognosis in acute myeloid leukemia (AML) and plays a crucial role in treatment decisions. Measurable residual disease (MRD) analysis of FLT3-ITD during and after treatment has shown prognostic value in adults, but its clinical value in children remains unexplored....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 42145040
DOI: 10.1002/1545-5017.70397

Genes

FLT3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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