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Article

Subclinical minute FLT3-ITD clone can be detected in clinically FLT3-ITD-negative acute myeloid leukaemia at diagnosis.

British journal of haematology - 1 Jun 2023

Yokoyama Shota, Onozawa Masahiro, Yoshida Shota, Miyashita Naoki, Kimura Hiroyuki, Takahashi Shogo, Matsukawa Toshihiro, Goto Hideki, Fujisawa Shinichi, Miki Kosuke, Hidaka Daisuke, Hashiguchi Junichi, Wakasa Kentaro, Ibata Makoto, Takeda Yukari, Shigematsu Akio, Fujimoto Katsuya, Tsutsumi Yutaka, Mori Akio, Ishihara Toshimichi, Kakinoki Yasutaka, Kondo Takeshi, Hashimoto Daigo, Teshima Takanori

Abstract excerpt

Recent advances in next-generation sequencing (NGS) have enabled the detection of subclinical minute FLT3-ITD. We selected 74 newly diagnosed, cytogenetically normal acute myeloid leukaemia (AML) samples in which FLT3-ITD was not detected by gel electrophoresis. We sequenced them using NGS and found minute FLT3-ITDs in 19 cases. We compared cases with clinically relevant FLT3-ITD (n = 37), cases with minute...

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PMID: 37067758
DOI: 10.1111/bjh.18800

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