Article
Clonal Dynamics of FLT3-ITD from Diagnosis to Relapse: Ultra-Sensitive Patient-Specific Monitoring by ddPCR.
International journal of molecular sciences - 8 Mar 2026
Ferrando Alessandro, Umurungi Johanna, Danzero Alice Costanza, Frolli Antonio, Vacca Rita, Savi Arianna, Fornari Giovanni, Gaidano Valentina, Cignetti Alessandro, Sani Beatrice, Rocco Simone, Pergolizzi Barbara, Fava Carmen, Panuzzo Cristina, Petiti Jessica, Cilloni Daniela
Abstract excerpt
The FLT3-ITD mutation is a critical prognostic marker in acute myeloid leukemia (AML) and recent clinical trials demonstrate that FLT3-based measurable residual disease (MRD) is both prognostic and predictive, guiding therapeutic interventions in intensive and post-transplant settings. Conventional detection methods lack the sensitivity required for effective MRD monitoring. We developed a patient-specific...
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