Quantitative fragment analysis of FLT3-ITD efficiently identifying poor prognostic group with high mutant allele burden or long ITD length.

doi:10.1038/bcj.2015.61

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Article

Quantitative fragment analysis of FLT3-ITD efficiently identifying poor prognostic group with high mutant allele burden or long ITD length.

Blood cancer journal - 14 Aug 2015

Kim Y, Lee G D, Park J, Yoon J-H, Kim H-J, Min W-S, Kim M

Abstract excerpt

Mutation of the fms-like tyrosine kinase 3-internal tandem duplication (FLT3-ITD), which is one of the most frequent genetic alterations, strongly contributes to an increased risk of treatment failure and to poor prognosis. In this study, we established quantitative fragment analysis of FLT3-ITD simultaneously measuring mutant allele burden and length, verified the analytical performance and evaluated the...

Topics

Adult
Female
Humans
Leukemia, Myeloid, Acute
Male
Middle Aged
Mutation
Polymerase Chain Reaction
Prognosis
fms-Like Tyrosine Kinase 3

Source

Open in PubMed Open full text

Identifiers

PMID: 26832846
DOI: 10.1038/bcj.2015.61
PMCID: PMC4558586

Genes

FLT3
EFS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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