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Article

FLT3-ITD mutations in acute myeloid leukaemia - molecular characteristics, distribution and numerical variation.

Molecular oncology - 1 Sept 2021

Engen Caroline, Hellesøy Monica, Grob Tim, Al Hinai Adil, Brendehaug Atle, Wergeland Line, Bedringaas Siv Lise, Hovland Randi, Valk Peter J M, Gjertsen Bjørn T

Abstract excerpt

Recurrent somatic internal tandem duplications (ITD) in the FMS-like tyrosine kinase 3 (FLT3) gene characterise approximately one third of patients with acute myeloid leukaemia (AML), and FLT3-ITD mutation status guides risk-adapted treatment strategies. The aim of this work was to characterise FLT3-ITD variant distribution in relation to molecular and clinical features, and overall survival in adult AML...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 33817952
DOI: 10.1002/1878-0261.12961
PMCID: PMC8410560

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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