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Body size, physical activity, genetic variants in the insulin-like growth factor pathway and colorectal cancer risk.

Carcinogenesis - 1 Sept 2015

Simons C C J M, Schouten L J, Godschalk R, van Engeland M, van den Brandt P A, van Schooten F J, Weijenberg M P

Abstract excerpt

Insulin-like growth factors (IGFs) have been associated with growth, body size, physical activity and colorectal cancer (CRC). We hypothesized that variants in IGF-related genes increase the CRC susceptibility associated with a larger body size and a lack of physical activity. We assessed this in The Netherlands Cohort Study. Participants (n = 120852) completed a baseline questionnaire on diet and cancer. ~75%...

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Identifiers

PMID: 26025909
DOI: 10.1093/carcin/bgv077

Genes

IGF1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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