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Article

Polymorphisms in the insulin-like growth factor axis are associated with gastrointestinal cancer.

PloS one - 1 Jan 2014

Ong Jennie, Salomon Jody, te Morsche Rene H M, Roelofs Hennie M J, Witteman Ben J M, Dura Polat, Lacko Martin, Peters Wilbert H M

Abstract excerpt

INTRODUCTION: Numerous factors influence the development of gastrointestinal (GI) cancer. The insulin-like growth factor (IGF) axis plays a role in embryonic and postnatal growth and tissue repair. Elevated levels of IGFs, low levels of IGF binding proteins (IGFBPs) and over-expression of IGF receptor (IGFR-I) were associated with several stages of cancer. Here, the prevalence of the single nucleotide...

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Source

Open in PubMed Open full text

Identifiers

PMID: 24608110
DOI: 10.1371/journal.pone.0090916
PMCID: PMC3946608

Genes

GHR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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