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Article

Energy restriction at young age, genetic variants in the insulin-like growth factor pathway and colorectal cancer risk in the Netherlands Cohort Study.

International journal of cancer - 15 Jan 2017

Simons Colinda C J M, Schouten Leo J, Godschalk Roger W, van Engeland Manon, van den Brandt Piet A, van Schooten Frederik J, Weijenberg Matty P

Abstract excerpt

The energy restriction (ER)-colorectal cancer (CRC) association is inconsistent in literature. To strengthen the biological plausibility of the ER-CRC association, we investigated whether genetic variation in the insulin-like growth factor (IGF) pathway, a putative underlying mechanism, modulated this association in the Netherlands Cohort Study. Participants completed a questionnaire (n = 120,852) and provided...

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Identifiers

PMID: 27649841
DOI: 10.1002/ijc.30439

Genes

IGF1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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