Article
Genes in the insulin and insulin-like growth factor pathway and odds of metachronous colorectal neoplasia.
Human genetics - 1 May 2011
LeRoy Elizabeth C, Moore Jason H, Hu Chengcheng, Martínez María Elena, Lance Peter, Duggan David, Thompson Patricia A
Abstract excerpt
Insulin and insulin-like growth factor (IGF) genes are implicated in colorectal carcinogenesis. Gene-by-gene interactions that influence the insulin/IGF pathways were hypothesized as modifiers of colorectal neoplasia risk. We built a classification tree to detect interactions in 18 IGF and insulin pathway-related genes and metachronous colorectal neoplasia among 1,439 subjects pooled from two chemoprevention...
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