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Article

Engineered Ionizable Side Chains.

Advances in experimental medicine and biology - 1 Jan 2015

Cymes Gisela D, Grosman Claudio

Abstract excerpt

One of the great challenges of mechanistic ion-channel biology is to obtain structural information from well-defined functional states. In the case of neurotransmitter-gated ion channels, the open-channel conformation is particularly elusive owing to its transient nature and brief mean lifetime. In this Chapter, we show how the analysis of single-channel currents recorded from mutants engineered to contain single...

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PMID: 26381938
DOI: 10.1007/978-1-4939-2845-3_2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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