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Article

Tunable pKa values and the basis of opposite charge selectivities in nicotinic-type receptors.

Nature - 22 May 2011

Cymes Gisela D, Grosman Claudio

Abstract excerpt

Among ion channels, only the nicotinic-receptor superfamily has evolved to generate both cation- and anion-selective members. Although other, structurally unrelated, neurotransmitter-gated cation channels exist, no other type of neurotransmitter-gated anion channel, and thus no other source of fast synaptic inhibitory signals, has been described so far. In addition to the seemingly straightforward electrostatic...

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Identifiers

PMID: 21602825
DOI: 10.1038/nature10015
PMCID: PMC3121909

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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