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Article

Ion Channel Conformation and Oligomerization Assessment by Site-Directed Spin Labeling and Pulsed-EPR.

Methods in enzymology - 1 Jan 2017

Pliotas Christos

Abstract excerpt

Mechanosensitive (MS) ion channels are multimeric integral membrane proteins that respond to increased lipid bilayer tension by opening their nonselective pores to release solutes and relieve increased cytoplasmic pressure. These systems undergo major conformational changes during gating and the elucidation of their mechanism requires a deep understanding of the interplay between lipids and proteins. Lipids are...

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Identifiers

PMID: 28779841
DOI: 10.1016/bs.mie.2017.05.013

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