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Article

Molecular mechanism of pH sensing in KcsA potassium channels.

Proceedings of the National Academy of Sciences of the United States of America - 13 May 2008

Thompson Ameer N, Posson David J, Parsa Pirooz V, Nimigean Crina M

Abstract excerpt

The bacterial potassium channel KcsA is gated by high concentrations of intracellular protons, allowing the channel to open at pH < 5.5. Despite prior attempts to determine the mechanism responsible for pH gating, the proton sensor has remained elusive. We have constructed a KcsA channel mutant t...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18443286
DOI: 10.1073/pnas.0800873105
PMCID: PMC2383984

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18443286-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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