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Article

Atomic mutagenesis in ion channels with engineered stoichiometry.

eLife - 6 Oct 2016

Lueck John D, Mackey Adam L, Infield Daniel T, Galpin Jason D, Li Jing, Roux Benoît, Ahern Christopher A

Abstract excerpt

C-type inactivation of potassium channels fine-tunes the electrical signaling in excitable cells through an internal timing mechanism that is mediated by a hydrogen bond network in the channels' selectively filter. Previously, we used nonsense suppression to highlight the role of the conserved Trp434-Asp447 indole hydrogen bond in Shaker potassium channels with a non-hydrogen bonding homologue of tryptophan, Ind...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Protein Conformation, alpha-Helical

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Source

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Identifiers

PMID: 27710770
DOI: 10.7554/eLife.18976
PMCID: PMC5092047

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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