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Article

Lysine scanning mutagenesis delineates structural model of the nicotinic receptor ligand binding domain.

The Journal of biological chemistry - 9 Aug 2002

Sine Steven M, Wang Hai-Long, Bren Nina

Abstract excerpt

Nicotinic acetylcholine receptors (AChR) and their relatives mediate rapid chemical transmission throughout the nervous system, yet their atomic structures remain elusive. Here we use lysine scanning mutagenesis to determine the orientation of residue side chains toward core hydrophobic or surface hydrophilic environments and use this information to build a structural model of the ligand binding region of the...

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Share to Binding, Competitive
Share to Crystallography, X-Ray
Share to DNA, Complementary

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Protein Structure, Secondary

Share to Receptors, Nicotinic

Source

Identifiers

PMID: 12011092
DOI: 10.1074/jbc.M203396200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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