Article
Side-chain conformation at the selectivity filter shapes the permeation free-energy landscape of an ion channel.
Proceedings of the National Academy of Sciences of the United States of America - 5 Aug 2014
Harpole Tyler J, Grosman Claudio
Abstract excerpt
On the basis of single-channel currents recorded from the muscle nicotinic acetylcholine receptor (AChR), we have recently hypothesized that the conformation adopted by the glutamate side chains at the first turn of the pore-lining α-helices is a key determinant of the rate of ion permeation. In this paper, we set out to test these ideas within a framework of atomic detail and stereochemical rigor by conducting...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.