Article
The coupling interface and pore domain codetermine the single-channel activity of the α7 nicotinic receptor.
Neuropharmacology - 1 Aug 2015
Yan Hongxia, Pan Na, Xue Fenqin, Zheng Yan, Li Chaokun, Chang Yongchang, Xu Zhiqing, Yang Hui, Zhang Jianliang
Abstract excerpt
Ligand-gated ion channels play a role in mediating fast synaptic transmission for communication between neurons. However, the structural basis for the functional coupling of the binding and pore domains, resulting in channel opening, remains a topic of intense investigation. Here, a series of α7 nicotinic receptor mutants were constructed for expression in cultured mammalian cells, and their single-channel...
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