Article
A unified view of the role of electrostatic interactions in modulating the gating of Cys loop receptors.
The Journal of biological chemistry - 16 Dec 2005
Xiu Xinan, Hanek Ariele P, Wang Jinti, Lester Henry A, Dougherty Dennis A
Abstract excerpt
In the Cys loop superfamily of ligand-gated ion channels, a global conformational change, initiated by agonist binding, results in channel opening and the passage of ions across the cell membrane. The detailed mechanism of channel gating is a subject that has lent itself to both structural and el...
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