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Article

Structural dynamics of the M4 transmembrane segment during acetylcholine receptor gating.

Structure (London, England : 1993) - 1 Oct 2004

Mitra Ananya, Bailey Timothy D, Auerbach Anthony L

Abstract excerpt

The transition state structures that link the stable end states of allosteric proteins are largely unresolved. We used single-molecule kinetic analysis to probe the dynamics of the M4 transmembrane segments during the closed<==>open isomerization of the neuromuscular acetylcholine receptor ion channel (AChR). We measured the slopes (phi) of the free energy relationships for 87 mutants, which reveal the open-...

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Identifiers

PMID: 15458639
DOI: 10.1016/j.str.2004.08.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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