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Article

Inclusion of homologous DNA in nuclease-mediated gene targeting facilitates a higher incidence of bi-allelically modified cells.

Xenotransplantation - 1 Jan 2000

Beaton Benjamin P, Kwon Deug-Nam, Choi Yun-Jung, Kim Jae-Hwan, Samuel Melissa S, Benne Joshua A, Wells Kevin D, Lee Kiho, Kim Jin-Hoi, Prather Randall S

Abstract excerpt

BACKGROUND: Recent advancements in gene editing techniques have increased in number and utility. These techniques are an attractive alternative to conventional gene targeting methods via homologous recombination due to the ease of use and the high efficiency of gene editing. We have previously produced cytidine monophosphate-N-acetylneuraminic acid hydroxylase (CMAH) knockout (KO) pigs in a Minnesota miniature...

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Share to Animals, Genetically Modified
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26381494
DOI: 10.1111/xen.12194
PMCID: PMC4584494

Genes

GGTA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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