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Article

Efficient generation of targeted and controlled mutational events in porcine cells using nuclease-directed homologous recombination.

The Journal of surgical research - 15 May 2017

Butler James R, Santos Rafael M N, Martens Gregory R, Ladowski Joseph M, Wang Zheng-Yu, Li Ping, Tector Matthew, Tector A Joseph

Abstract excerpt

BACKGROUND: Nuclease-based genome editing has rapidly sped the creation of new models of human disease. These techniques also hold great promise for the future of clinical xenotransplantation and cell-based therapies for cancer or immunodeficient pathology. However, to fully realize the potential of nuclease editing tools, the efficiency and precision of their application must be optimized. The object of this...

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Identifiers

PMID: 28550913
DOI: 10.1016/j.jss.2017.01.025

Genes

GGTA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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