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Article

Efficient bi-allelic gene knockout and site-specific knock-in mediated by TALENs in pigs.

Scientific reports - 5 Nov 2014

Yao Jing, Huang Jiaojiao, Hai Tang, Wang Xianlong, Qin Guosong, Zhang Hongyong, Wu Rong, Cao Chunwei, Xi Jianzhong Jeff, Yuan Zengqiang, Zhao Jianguo

Abstract excerpt

Pigs are ideal organ donors for xenotransplantation and an excellent model for studying human diseases, such as neurodegenerative disease. Transcription activator-like effector nucleases (TALENs) are used widely for gene targeting in various model animals. Here, we developed a strategy using TALENs to target the GGTA1, Parkin and DJ-1 genes in the porcine genome using Large White porcine fibroblast cells without...

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Source

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Identifiers

PMID: 25370805
DOI: 10.1038/srep06926
PMCID: PMC4220281

Genes

GGTA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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