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Article

Production of biallelic CMP-Neu5Ac hydroxylase knock-out pigs.

Scientific reports - 1 Jan 2013

Kwon Deug-Nam, Lee Kiho, Kang Man-Jong, Choi Yun-Jung, Park Chankyu, Whyte Jeffrey J, Brown Alana N, Kim Jae-Hwan, Samuel Melissa, Mao Jiude, Park Kwang-Wook, Murphy Clifton N, Prather Randall S, Kim Jin-Hoi

Abstract excerpt

After the knock-out (KO) of α1,3 galactosyltransfease (Gal-T), the Hanganutziu-Deicher antigen became a major antigen of the "non-Gal antigen" that is implicated in subsequent xenograft rejection. For deletion of non-Gal antigen, we successfully produced zinc finger nuclease (ZFN)-mediated monoallelic/biallelic male and female CMP-N-acetylneuraminic acid hydroxylase (CMAH) KO miniature pigs: the efficiency of the...

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Identifiers

PMID: 23760311
DOI: 10.1038/srep01981
PMCID: PMC4070623

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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